| 论文题目 | MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O-2 self-sufficient photodynamic therapy |
| 作 者 | ; Ding Binbin,Shao Shuai,Xiao Haihua, Sun Chunqiang, Cai Xuechao, Jiang Fan,Zhao Xueyan, Ma Ping'an, Jun Lin |
| 发表年度 | AUG 21 2019 |
| 刊物名称 | NANOSCALE |
| 卷、期、页码 | 11; 31; 14654-14667 |
| 影响因子 | |
| 论文摘要 | The limited light penetration depth and tumor hypoxia are two natural shortcomings of photodynamic therapy (PDT). Overcoming these two issues within a single system is still a great challenge. Herein, photosensitizer (PS)-loaded and PEG-modified MnFe2O4-decorated large-pore mesoporous silica-coated beta-NaYF4:20%Yb,2%Er@beta-NaYF4 upconversion nanoparticles (UCMnFe-PS-PEG) as excellent PDT agents are successfully prepared for NIR light-mediated and O-2 self-sufficient PDT. The large mesoporous structure observably increases PS loading efficiency (11.33 wt%) and the green luminescence from upconversion nanoparticles activated by NIR is able to activate PSs to generate ROS effectively. In addition, sub-10 nm MnFe2O4 nanoparticles work as a Fenton catalyst to generate O(2)in situ. In vivo experiments further prove that UCMnFe-PS-PEG not only provides magnetic guidance to the tumor, but also overcomes tumor hypoxia and dramatically enhances PDT efficiency. Furthermore, in vivo MR and UCL imaging are performed for accurate cancer therapy. We believe that the successful construction of the multifunctional UCMnFe-PS-PEG provides more revelations for developing advanced nano-drug systems for cancer therapy. |
| 全文链接 | https://pubs.rsc.org/en/content/articlelanding/2019/NR/C9NR04858H#!divAbstract |
| 附件地址 |
研究队伍