| 论文题目 | Yolk-Shell Structured Au Nanostar@Metal-Organic Framework for Synergistic Chemo-photothermal Therapy in the Second Near-Infrared Window |
| 作 者 | ; Liang Shuang, Deng Xiaoran,Cai, S. S.Huang, Y. S. Shi, M. L. Pang, P. A. Ma, Z. Y. Cheng*, J. Lin* |
| 发表年度 | OCT 2019 |
| 刊物名称 | NANO LETTERS |
| 卷、期、页码 | 19; 10; 6772-6780 |
| 影响因子 | |
| 论文摘要 | Light-sensitive yolk-shell nanoparticles (YSNs) as remote-controlled and stimuli-responsive theranostic platforms provide an attractive method for synergistic cancer therapy. Herein, a kind of novel stimuli-responsive multifunctional YSNs has been successfully constructed by integrating star-shaped gold (Au star) nanoparticles as the second near-infrared (NIR-II) photothermal yolks and biodegradable crystalline zeolitic imidazolate framework-8 (ZIF-8) as the shells. In this platform, a chemotherapeutic drug (doxorubicin hydrochloride, DOX) was encapsulated into the cavity, which can show the behavior of controlled release due to the degradation process of ZIF-8 in the mildly acidic tumor microenvironment. Upon the 1064 nm (NIR-II biowindow) laser irradiation, gold nanostar@ZIF-8 (Au@MOF) nanoparticles exhibited outstanding synergistic anticancer effect based on their photothermal and promoted cargo release properties. Moreover, the strong NIR region absorbance endows the Au@MOF of NIR thermal imaging and photoacoustic (PA) imaging properties. This work contributes to design a stimuli responsive "all-in-one" nanocarrier that realizes bimodal imaging diagnosis and chemo-photothermal synergistic therapy. |
| 全文链接 | https://pubs.acs.org/doi/10.1021/acs.nanolett.9b01716 |
| 附件地址 |
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