| 论文题目 | One-Pot Synthesis of DOX@Covalent Organic Framework with Enhanced Chemotherapeutic Efficacy |
| 作 者 | ; Sainan Liu,Chunling Hu, Ying Liu, Xueyan Zhao,Maolin Pang* and Jun Lin* |
| 发表年度 | MAR 21 2019 |
| 刊物名称 | CHEMISTRY-A EUROPEAN JOURNAL |
| 卷、期、页码 | 25; 17; 4315-4319 |
| 影响因子 | |
| 论文摘要 | Covalent organic frameworks (COFs) have attracted great attention across diverse research fields. However, only a few reports about the biomedical application of COFs are found in the literature. Attributed to the highly porous and tunable structure, as well as good thermal stability, COFs show great potential as drug carriers for chemotherapy. In this work, doxorubicin (DOX) was successfully in situ loaded into a COF by a one-pot method for the first time. The resultant DOX@COF platform exhibited high drug-loading capacity (32.1 wt %) and pH-responsive release property. In vitro and in vivo experiments demonstrated its good biocompatibility and enhanced antitumor efficacy. |
| 全文链接 | DOI:？10.1002/chem.201806242 |
| 附件地址 |
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